Student Papers

2014

2013

2012 2011 2010 2009 2008 2007

2014

  • Sörensen PM, Iacob RE, Fritzsche M, Engen JR, Brieher WM, Charras G, Eggert US. The natural product cucurbitacin E inhibits depolymerization of actin filaments. ACS Chem Biol. 2012 Sep 21;7(9):1502-8. PMCID: PMC3448819.
  • Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9932-7. doi:
    10.1073/pnas.1302257110. Epub 2013 May 28. PubMed PMID: 23716698; PubMed Central PMCID: PMC3683768.
  • Lee S, Braun CR, Bird GH, Walensky LD. Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry. Methods Enzymol. 2014;544:25-48. doi: 10.1016/B978-0-12-417158-9.00002-9. PubMed PMID: 24974285.
  • Leshchiner ES, Braun CR, Bird GH, Walensky LD. Direct activation of full-length proapoptotic BAK. Proc Natl Acad Sci U S A. 2013 Mar 12;110(11):E986-95. doi: 10.1073/pnas.1214313110. Epub 2013 Feb 12. PubMed PMID: 23404709; PubMed Central PMCID: PMC3600461.
  • Carlson, J. C.; Badran, A. H.; Guggiana-Nilo, D. A.; Liu, D. R. (2014) Negative selection and stringency modulation in phage-assisted continuous evolution. Nature Chemical Biology, 10, 216-222 PMCID: PMC3977541
  • Freinkman E, Okuda S, Ruiz N, Kahne D. Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export. Biochemistry. 2012 Jun 19;51(24):4800-6. doi: 10.1021/bi300592c. Epub 2012 Jun 8. PubMed PMID: 22668317; PubMed Central PMCID: PMC3426634.
  • Okuda S, Freinkman E, Kahne D. Cytoplasmic ATP hydrolysis powers transport of  lipopolysaccharide across the periplasm in E. coli. Science. 2012 Nov 30;338(6111):1214-7. doi: 10.1126/science.1228984. Epub 2012 Nov 8. PubMed PMID: 23138981; PubMed Central PMCID: PMC3552488.
  • Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature. 2013 Feb 28;494(7438):480-3. doi: 10.1038/nature11897. PubMed PMID: 23446419; PubMed Central PMCID: PMC3730528.
  • McGregor LM, Jain T, Liu DR. Identification of ligand-target pairs from combined libraries of small molecules and unpurified protein targets in cell lysates. J Am Chem Soc. 2014 Feb 26;136(8):3264-70. doi: 10.1021/ja412934t. Epub 2014 Feb 17. PubMed PMID: 24495225; PubMed Central PMCID: PMC3985698.
  • Santa Maria JP Jr, Sadaka A, Moussa SH, Brown S, Zhang YJ, Rubin EJ, Gilmore MS, Walker S. Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12510-5. doi: 10.1073/pnas.1404099111. Epub 2014 Aug 7. PubMed PMID:25104751; PubMed Central PMCID: PMC4151746.
  • McKeown MR, Bradner JE. Therapeutic strategies to inhibit MYC. Cold Spring Harb Perspect Med. 2014 Oct 1;4(10). pii: a014266. doi:
    10.1101/cshperspect.a014266. PubMed PMID: 25274755.
  • McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE. Biased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem. 2014 Nov 13;57(21):9019-27. doi: 10.1021/jm501120z. Epub 2014 Oct 31. PubMed PMID: 25314271; PubMed Central PMCID: PMC4234447.
  • Strittmatter, L., Li, Y., Nakatsuka, N.J., Calvo, S.E., Grabarek, Z., Mootha, V.K., 2014, “CLYBL is a polymorphic human enzyme with malate synthase and β-methylmalate synthase activity,” Hum. Mol. Genet., 23(9):2313-23. PMCID 24334609
  • Tan JL, Zon LI. Chemical screening in zebrafish for novel biological and therapeutic discovery. Methods Cell Biol. 2011;105:493-516. doi: 10.1016/B978-0-12-381320-6.00021-7. PubMed PMID: 21951544.
  • Nguyen PA,  Groen AC,  Loose M,  Ishihara K,  Wühr M,  Field CM,  Mitchison TJ., Spatial organization of cytokinesis signaling reconstituted in a cell-free system. Science. 2014 Oct 10;346(6206):244-7. doi: 10.1126/science.1256773. PubMed PMID: 25301629.
  • Ankarklev J, Brancucci NM, Goldowitz I, Mantel PY, Marti M. Sex: how malaria parasites get turned on. Curr Biol. 2014 May 5;24(9):R368-70. doi:
    10.1016/j.cub.2014.03.046. PubMed PMID: 24801188.
  • Badran AH, Liu DR. In vivo continuous directed evolution. Curr Opin Chem Biol. 2014 Nov 7;24C:1-10. doi: 10.1016/j.cbpa.2014.09.040. [Epub ahead of print] Review. PubMed PMID: 25461718.
  • Lu, A., Magupalli, V. G., Ruan, J., Yin, Q., Atianand, M. K., Vos, M. R., Schroder, G. F., Fitzgerald, K. A., Wu, H. & Egelman, E. H. (2014) Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes, Cell. 156, 1193-206. PMID: 24630722
  • Lu, A., Kabaleeswaran, V., Fu, T., Magupalli, V. G. & Wu, H. (2014) Crystal structure of the F27G AIM2 PYD mutant and similarities of its self-association to DED/DED interactions, Journal of molecular biology. 426, 1420-7. PMID: 24406744
  • Federation, A.J., Bradner, J.E., Meissner, A., 2014, “The use of small molecules in somatic-cell reprogramming.” Trends in cell biology, 24:179-87. PMID: 24183602
  • Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S. Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction. J Am Chem Soc. 2014 Oct 22;136(42):14678-81. doi:10.1021/ja508147s. Epub 2014 Oct 10. PubMed PMID: 25291014; PubMed Central PMCID:PMC4210121.
  • Wang F, Chan C, Weir NR, Denic V. The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase. Nature. 2014 Aug
    28;512(7515):441-4. doi: 10.1038/nature13471. Epub 2014 Jul 20. PubMed PMID:25043001.
  • Sourav Banerjee, S., Buhrlage, S.J., Huang, H.-T., Deng, X., Zhou, W., Wang, J., Traynor, R., Prescott, A.R., Alessi, D.R., Gray, N.S., 2014, "Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases," Biochem. J. 457, 215-225. PMCID: PMC3969223
  • Meier, B.C. and Wagner, B.K., 2014, "Inhibition of HDAC3 as a Strategy for Developing Novel Diabetes Therapeutics," Epigenomics, 6(2): 209-214, PMID: 24811789.
  • Hochbaum, D.R., Zhao, Y., Farhi, S.L., Klapoetke, N., Werley, C.A., Kapoor, V., Kralj, J.M., Maclaurin, D., Smedemark-Margulies, N., Saulnier, J.L., Boulting, G.L., Straub, C., Cho, Y.K., Melkonian, M., Wong, G.K., Harrison, D.J., Murthy, V.N., Sabatini, B.L., Boyden, E.S., Campbell, R.E., and Cohen, A.E., 2014, "All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins," Nature Methods, Vol 11, 825-33. PMCID: PMC4117813

 

2013

  • Lajoie MJ, Kosuri S, Mosberg JA, Gregg CJ, Zhang D, Church GM. Probing the limits of genetic recoding in essential genes. Science. 2013 Oct 18;342(6156):361-3. doi: 10.1126/science.1241460. PubMed PMID: 24136967.

  • Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FJ. Genomically recoded organisms expand biological functions. Science. 2013 Oct 18;342(6156):357-60. doi: 10.1126/science.1241459. PubMed PMID: 24136966.

  • Ling J, Daoud R, Lajoie MJ, Church GM, Söll D, Lang BF. Natural reassignment of CUU and CUA sense codons to alanine in Ashbya mitochondria. Nucleic Acids Res. 2014 Jan;42(1):499-508. doi: 10.1093/nar/gkt842. Epub 2013 Sep 17. PubMed PMID:24049072; PubMed Central PMCID: PMC3874161.

  • Pasquina LW, Santa Maria JP, Walker S. Teichoic acid biosynthesis as an antibiotic target. Curr Opin Microbiol. 2013 Oct;16(5):531-7. doi:10.1016/j.mib.2013.06.014. Epub 2013 Jul 31. Review. PubMed PMID: 23916223; PubMed Central PMCID: PMC3834221.

  • Brown S, Santa Maria JP Jr, Walker S. Wall teichoic acids of gram-positive bacteria. Annu Rev Microbiol. 2013;67:313-36. doi:10.1146/annurev-micro-092412-155620. Review. PubMed PMID: 24024634; PubMed Central PMCID: PMC3883102

  • Plovanich M, Bogorad RL, Sancak Y, Kamer KJ, Strittmatter L, Li AA, Girgis HS, Kuchimanchi S, De Groot J, Speciner L, Taneja N, Oshea J, Koteliansky V, Mootha VK. MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling. PLoS One. 2013;8(2):e55785. doi: 10.1371/journal.pone.0055785. Epub 2013 Feb 7.

  • Mantel, P. Y., *A. N. Hoang, *I. Goldowitz, *D. Potashnikova, B. Hamza, I. A. Vorobjev, I. Ghiran, M. Toner, D. Irimia, R. Ivanov, N. Barteneva, M. Marti (2013). Malaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system. Cell Host and Microbe 13, 521-534. PMID: 23684304

  • Kawate, T., Iwase, N., Shimizu, M., Stanley, S.A., Wellington, S., Kazyanskaya, E., Hung, D.T. (2013). Synthesis and Structure-Activity Relationships of Phenyl-substituted Coumarins with anti-tubercular
    activity that target FadD32, Bioorganic & Medicinal Chemistry Letters 23(22), 6052–6059. doi:10.1016/j.bmcl.2013.09.035. Epub 2013 Sept 19. Pubmed PMID:24103299

2012

  • Yuan Yuan, Qiu Wang, Joshiawa Paulk, Stefan Kubicek, Melissa M. Kemp, Drew J. Adams, Alykhan F. Shamji, Bridget K. Wagner, and Stuart L. Schreiber. 1. A Small-Molecule Probe of the Histone Methyltransferase G9a Induces Cellular Senescence in Pancreatic Adenocarcinoma. ACS Chemical Biology 2012 7 (7), 1152-1157. PMCID:PMC3401036
  • Carr PA*, Wang HH*, Sterling B*, Isaacs FJ, Lajoie MJ, Xu G, Church GM, Jacobson JM (2012) Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection. NAR; doi: 10.1093/nar/gks455
  • Lajoie MJ*, Gregg CJ*, Mosberg JA*, Washington GC, Church GM (2012) Manipulating Replisome Dynamics to Enhance Lambda Red-Mediated Multiplex Genome Engineering. NAR; doi: 10.1093/nar/gks751
  • Mosberg JA*, Gregg CJ*, Lajoie MJ*, Wang HH, Church GM (2012) Improving Lambda Red Genome Engineering in Escherichia coli via Rational Removal of Endogenous Nucleases. PLoS ONE 7(9): e44638. doi:10.1371/journal.pone.0044638
  • Mosberg JA*, Gregg CJ*, Lajoie MJ*, Wang HH, Church GM (2012) Improving Lambda Red Genome Engineering in Escherichia coli via Rational Removal of Endogenous Nucleases. PLoS ONE 7(9): e44638. doi:10.1371/journal.pone.0044638
  • Mitchison T, Wühr M, Nguyen PA, Ishihara K, Groen A, Field CM. Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells. Cytoskeleton (Hoboken). 2012 Oct;69(10):738-50. doi:
  • Maiuri P, Terriac E, Paul-Gilloteaux P, Vignaud T, McNally K, Onuffer J, Thorn K, Nguyen PA, Georgoulia N, Soong D, Jayo A, Beil N, Beneke J, Hong Lim JC, Pei-Ying Sim C, Chu YS; WCR participants, Jiménez-Dalmaroni A, Joanny JF, Thiery JP, Erfle H, Parsons M, Mitchison TJ, Lim WA, Lennon-Duménil AM, Piel M, Théry M. The first World Cell Race. Curr Biol. 2012 Sep 11;22(17):R673-5. 
  • Matzuk MM, McKeown MR, Filippakopoulos P, Li Q, Ma L, Agno JE, Lemieux ME, Picaud S, Yu RN, Qi J, Knapp S, Bradner JE. Small-molecule inhibition of BRDT for male contraception. Cell. 2012 Aug 17; 150(4):673-684
  • Nguyen PA, Ishihara K, Wühr M, Mitchison TJ. Pronuclear migration: no attachment? No union, but a futile cycle! Curr Biol. 2012 May 22;22(10):R409-11. 
  • Leoni V*, Strittmatter L*, Zorzi G, Zibordi F, Dusi S, Garavaglia B, Venco P, Caccia C, Souza AL, Deik A, Clish CB, Rimoldi M, Ciusani E, Bertini E, Nardocci N, Mootha VK, Tiranti V. Metabolic consequences of mitochondrial coenzyme A deficiency in patients with PANK2 mutations. Mol Genet Metab. 2012 Mar;105(3):463-71 (* indicates equal contribution)
  • Weigert O, Lane AA, Bird L, Kopp N, Chapuy B, van Bodegom D, Toms AV, Marubayashi S, Christie AL, McKeown M, Paranal RM, Bradner JE, Yoda A, Gaul C, Vangrevelinghe E, Romanet V, Murakami M, Tiedt R, Ebel N, Evrot E, De Pover A, Régnier CH, Erdmann D, Hofmann F, Eck MJ, Sallan SE, Levine RL, Kung AL, Baffert F, Radimerski T, Weinstock DM. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. J Exp Med. 2012 Feb 13; 208(2):259-73
  • Nakamura H, Hamer HA, Sirasani G, Balskus EP. Cylindrocyclophane Biosynthesis Involves Functionalization of an Unactivated Carbon Center.JACS 2012 ASAP.
  • Lajoie MJ*, Gregg CJ*, Mosberg JA*, Washington GC, Church GM (2012) Manipulating Replisome Dynamics to Enhance Lambda Red-Mediated Multiplex Genome Engineering. NAR; doi: 10.1093/nar/gks751

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2011

  • Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, Kastritis E, Gilpatrick T, Paranal RM, Qi J, Chesi M, Schinzel AC, McKeown MR, Heffernan TP, Vakoc CR, Bergsagel PL, Ghobrial IM, Richardson PG, Young RA, Hahn WC, Anderson KC, Kung AL, Bradner JE, Mitsiades CS. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011 Sep 16; 146(6):904-17
  • Crawford JM, Portmann C, Kontnik R, Walsh CT, Clardy J. NRPS Substrate Promiscuity Diversifies the Xenematides. Org Lett. 2011 Oct 7;13(19):5144-7. PMCID: PMC3184645.
  • Crawford JM, Mahlstedt SA, Malcolmson SJ, Clardy J, Walsh CT. Dihydrophenylalanine: A Prephenate-Derived Photorhabdus luminescens Antibiotic and Intermediate in Dihydrostilbene Biosynthesis. Chem Biol. 2011 Sep 23;18(9):1102-12.PMCID: PMC3183431.
  • Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR. GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Mol Microbiol. 2011 Sep;81(5):1390-401.
  • Zhang J, Roberts TM, Shivdasani RA. Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology. 2011 Jul;141(1):50-61.
  • Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, Shih AF, May EM, Cepko CL, Kung AL, Zhou Q, Liu DR. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol. 2011 Jul 29;18(7):833-8. PMCID: PMC3154086.
  • Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, Shih AF, May EM, Cepko CL, Kung AL, Zhou Q, Liu DR. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol. 2011 Jul 29;18(7):833-8. PMCID: PMC3154086.
  • Isaacs FJ, Carr PA, Wang HH, Lajoie MJ, Sterling B, Kraal L, Tolonen AC, Gianoulis TA, Goodman DB, Reppas NB, Emig CJ, Bang D, Hwang SJ, Jewett MC, Jacobson JM, Church GM. Precise manipulation of chromosomes in vivo enables genome-wide codon replacement. Science. 2011 Jul 15;333(6040):348-53.
  • Baughman JM, Perocchi F, Girgis HS, Plovanich M, Belcher-Timme CA, Sancak Y, Bao XR, Strittmatter L, Goldberger O, Bogorad RL, Koteliansky V, Mootha VK. Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. Nature. 2011 Jun 19;476(7360):341-5.
  • Peck SH, Chen I, Liu DR. Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cells. Chem Biol. 2011 May 27;18(5):619-30. PMCID: PMC3124510.
  • Schirner K, Stone LK, Walker S. ABC transporters required for export of wall teichoic acids do not discriminate between different main chain polymers. ACS Chem Biol. 2011 May 20;6(5):407-12. PMCID: PMC3098905.
  • Hollenhorst MA, Ntai I, Badet B, Kelleher NL, Walsh CT. A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway. Biochemistry. 2011 May 17;50(19):3859-61. PMCID: PMC3097904.
  • Esvelt KM, Carlson JC, Liu DR. A system for the continuous directed evolution  of biomolecules. Nature. 2011 Apr 28;472(7344):499-503. PMCID: PMC3084352.
  • Karanicolas J, Corn JE, Chen I, Joachimiak LA, Dym O, Peck SH, Albeck S, Unger T, Hu W, Liu G, Delbecq S, Montelione GT, Spiegel CP, Liu DR, Baker D. A de novo protein binding pair by computational design and directed evolution. Mol Cell.2011 Apr 22;42(2):250-60. PMCID: PMC3102007.
  • Chen X, Tukachinsky H, Huang CH, Jao C, Chu YR, Tang HY, Mueller B, Schulman S, Rapoport TA, Salic A. Processing and turnover of the Hedgehog protein in the endoplasmic reticulum. J Cell Biol. 2011 Mar 7;192(5):825-38. PMCID: PMC3051819.
  • Freinkman E, Chng SS, Kahne D. The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel. Proc Natl  Acad Sci U S A. 2011 Feb 8;108(6):2486-91. PMCID: PMC3038725.
  • Campbell J, Singh AK, Santa Maria JP Jr, Kim Y, Brown S, Swoboda JG, Mylonakis E, Wilkinson BJ, Walker S. Synthetic lethal compound combinations reveal a fundamental connection between wall teichoic acid and peptidoglycan biosyntheses in Staphylococcus aureus. ACS Chem Biol. 2011 Jan 21;6(1):106-16. PMCID: PMC3025082.
  • Mosimann C, Kaufman CK, Li P, Pugach EK, Tamplin OJ, Zon LI. Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish. Development. 2011 Jan;138(1):169-77. PMCID: PMC2998170.
  • Li P, White RM, Zon LI. Transplantation in zebrafish. Methods Cell Biol. 2011;105:403-17.
  • Li P, Zon LI. Stem cell migration: a zebrafish model. Methods Mol Biol. 2011;750:157-68.

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2010

  • Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE. Selective inhibition of BET bromodomains. Nature. 2010 Dec 23; 468(7327):1067-73
  • Braun CR, Mintseris J, Gavathiotis E, Bird GH, Gygi SP, Walensky LD. Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome. Chem Biol. 2010 Dec 22;17(12):1325-33. PMCID:PMC3048092.
  • Mosberg JA, Lajoie MJ, Church GM. Lambda red recombineering in Escherichia coli occurs through a fully single-stranded intermediate. Genetics. 2010 Nov;186(3):791-9. PMCID:PMC2975298.
  • McGregor LM, Gorin DJ, Dumelin CE, Liu DR. Interaction-dependent PCR:identification of ligand-target pairs from libraries of ligands and libraries of targets in a single solution-phase experiment. J Am Chem Soc. 2010 Nov 10;132(44):15522-4. PMCID: PMC2974369.
  • Mosberg JA, Lajoie MJ, Church GM. Lambda red recombineering in Escherichia coli occurs through a fully single-stranded intermediate. Genetics. 2010 Nov;186(3):791-9. PMCID: PMC2975298.
  • Hollenhorst MA, Bumpus SB, Matthews ML, Bollinger JM Jr, Kelleher NL, Walsh CT. The nonribosomal peptide synthetase enzyme DdaD tethers N(β)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. J Am Chem Soc. 2010 Nov 10;132(44):15773-81. Erratum in: J Am Chem Soc. 2011 Feb 9;133(5):1609. PMCID: PMC2974046.
  • Mahlstedt S, Fielding EN, Moore BS, Walsh CT. Prephenate decarboxylases: a new prephenate-utilizing enzyme family that performs nonaromatizing decarboxylation en route to diverse secondary metabolites. Biochemistry. 2010 Oct  26;49(42):9021-3.PMCID: PMC2957524.
  • Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR. Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein. ACS Chem Biol. 2010 Aug 20;5(8):747-52. PMCID: PMC2924640.
  • Kontnik R, Crawford JM, Clardy J. Exploiting a global regulator for small molecule discovery in Photorhabdus luminescens. ACS Chem Biol. 2010 Jul 16;5(7):659-65.PMCID: PMC2912427.
  • Li P, Zon LI. Resolving the controversy about N-cadherin and hematopoietic stem cells. Cell Stem Cell. 2010 Mar 5;6(3):199-202.
  • Mahlstedt SA, Walsh CT. Investigation of anticapsin biosynthesis reveals a four-enzyme pathway to tetrahydrotyrosine in Bacillus subtilis. Biochemistry. 2010 Feb 9;49(5):912-23. PMCID: PMC2819075.
  • Phelps CB, Wang RR, Choo SS, Gaudet R. Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. J Biol Chem. 2010 Jan 1;285(1):731-40. PMID: 19864432

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2009

  • Crawford JM, Kontnik R, Clardy J. Regulating Alternative Lifestyles in Entomopathogenic Bacteria. Curr Biol. 2009 Dec 16. PMID: 20022247
  • Chen, Y. G.; Kowtoniuk, W. E.; Agarwal, I.; Shen, Y.; Liu, D. R. LC/MS analysis of cellular RNA reveals NAD-linked RNA. Nat Chem Biol. 2009 Dec;5(12):879-81. PMID: 19820715 58. Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions
  • Jao CY, Salic A. Metabolic labeling and direct imaging of choline-containing phospholipids in vivo. Proc Natl Acad Sci U S A. 2009 Aug 20. PMID: 19706413
  • Hollenhorst MA, Clardy J, Walsh CT. The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics. Biochemistry. 2009 Nov 3;48(43):10467-72. Erratum in: Biochemistry. 2010 Jul 27;49(29):6296. PMCID: PMC2783456.
  • Heemstra, J. M.; Liu, D. R. submitted (2009).59. An In Vitro Selection System for Peptide Nucleic Acid
  • North TE, Goessling W, Peeters M, Li P, Ceol C, Lord AM, Weber GJ, Harris J, Cutting CC, Huang P, Dzierzak E, Zon LI. (2009). Hematopoietic stem cell development is dependent on blood flow and nitric oxide signaling. Cell 137(4):736-48. PMCID: PMC2722870
  • McNaughton, B. R.; Cronican, J. J.; Thompson, D.B.; Liu, D. R. Mammalian Cell Penetration, siRNA Transfection, and DNA Transfection by Supercharged Proteins. Proc. Natl. Acad. Sci. USA 106, 6111-6116 (2009). PMCID: PMC2659711
  • Freinkman E., Oh D.-C., Scott J.J., Currie C.R., and Clardy J.  Bionectriol A, a polyketide glycoside from the fungus Bionectria sp. associated with the fungus-growing ant, Apterostigma dentigerum.  Tetrahedron Lett. 50(2009): 6834-6837.

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2008

  • Kontnik R, Bosak T, Butcher RA, Brocks JJ, Losick R, Clardy J, and Pearson A. Sporulenes, heptaprenyl metabolites from Bacillus subtilis spores. Org Lett. 2008; 10(16):3551-4. PMCID: PMC2646877
  • Kontnik R, Clardy J. Codinaeopsin, an antimalarial fungal polyketide. Org Lett. 2008; 10(18):4149-51. PMCID: PMC2626159
  • Jao CY, Salic A. Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15779-84. PMCID: PMC2572917
  • Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti S, Loda M, Roberts TM, Zhao JJ. Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature. 2008 Aug 7;454(7205):776-9. PMCID: PMC2750091.
  • Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R. Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry. 2008 Feb 26;47(8):2476-84. PMID: 18232717

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2007

  • Phelps CB, Procko E, Lishko PV, Wang RR, Gaudet R. Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels (Austin). 2007 May-Jun;1(3):148-51. PMID: 18690026
  • Phelps CB, Procko E, Lishko PV, Wang RR, Gaudet R. Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels (Austin). 2007 May-Jun;1(3):148-51. PMID: 18690026
  • Yin J, Straight PD, Hrvatin S, Dorrestein PC, Bumpus SB, Jao CY, Kelleher NL, Kolter R, Walsh CT. Genome-wide high-throughput mining of natural-product biosynthetic gene clusters by phage display. Chem Biol. 2007 Mar;14(3):303-12. PMID: 17379145

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