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Nathalie Agar

Associate Professor of Radiology

Brigham and Womens Hospital
Neurosurgery, BLI, room 137
221 Longwood Ave
Boston MA 02115
Tel: 617-525-7374

Emily Balskus

Associate Professor of Chemistry and Chemical Biology

Discovery of new natural product biosynthetic pathways; study of enzymatic transformations from the human microbiota; development of biocompatible chemistry that can be interfaced with living systems.

Stephen C. Blacklow

Professor of Biological Chemistry and Molecular Pharmacology

Research in the Blacklow laboratory is centered around the molecular logic of normal and pathogenic Notch signaling. Activating mutations in human Notch1 are found in more than half of human T-cell leukemias, and a key goal of current research is therefore to develop new classes of selective Notch inhibitors.

Sara Buhrlage

Assistant Professor of BCMP

Dysregulation of protein homeostasis drives many types of cancer, infection and neurodegeneration.  The mission of our group is to develop first-in-class inhibitors and prototype drugs for deubiquitylating enzymes, a class of enzymes responsible for regulating proteostasis, that can be utilized to pharmacologically validate members of the gene family as new targets for cancer treatment and other diseases.

Edward Chouchani

Assistant Professor of Cell Biology

Our research focuses on deciphering the molecular mechanisms of metabolic disease, and using this information to develop targeted therapeutic strategies.  We apply mass spectrometry, biochemical, and genetic approaches to identify mitochondrial metabolic pathways that control protective and pathological cascades initiated by this organelle.

Amit Choudhary

Assistant Professor of Medicine

Chemical biology of insulin-producing beta cells; Technology development

Stirling Churchman

Assistant Professor of Genetics

We are interested in understanding the molecular mechanisms that control and coordinate transcription and co-transcriptional processes, including splicing, chromatin remodeling and termination.

Jon Clardy

Hsien Wu and Daisy Yen Wu Professor of Biological Chemistry and Molecular Pharmacology, Program Co-director

Discovery of naturally occurring small molecules, chemical ecology, antibiotics

Adam Cohen

Professor of Chemistry and Chemical Biology and of Physics

The Cohen Lab develops physical tools to study molecules and cells.  They work on imaging voltage in brains, hearts, embryos, and microorganisms; we study DNC mechanics; they study the effects of weak magnetic fields on chemical reactions; and they study the fundamental physics of light-matter interactions.

Philip Cole

Professor of Medicine

Our research involves the chemical biology of protein post-translational modifcations (PTMs) in the context of signaling, epigenetics, and cancer.  We develop and apply chemical approaches including protein semisynthesis and small molecule probes to the study of protein phosphorylation, acetylation, ubiquitination and other PTMs in enzymes and cellular networks.

Vlad Denic

Associate Professor of Molecular and Cellular Biology

Lipidomics, insertion of tail-anchored proteins into lipid bilayers, assembly of lipids into the double autophagosomal membrane.

Sloan Devlin

Assistant Professor of BCMP

Small molecules to study and manipulate human-associated bacteria in order to better understand how the microbiome affects human health and disease.

Eric Fischer

Assistant Professor of BCMP

We combine structural biology, cell biology and biochemical reconstitutions to address the mechanistic principles that govern signaling through the ubiquitin proteasome system. We seek to leverage our molecular understanding to propose and test new avenues of therapeutic intervention.

Rachelle Gaudet

Professor of Molecular and Cellular Biology

Structural biology of ion channels and transporters: The Gaudet lab uses a combination of structural, biophysical and biochemical approaches to study signaling and transport through biological membranes. Particular systems of interest are ABC transporters and thermosensing TRP ion changes.

David Golan

Professor of Biological Chemistry and Molecular Pharmacology Dean for Graduate Education, HMS

Our goals are to understand the molecular interactions controlling protein and lipid mobility and distribution in cell membranes, the roles these mechanisms play in interactions between cells, and the relationships between derangements in these mechanism and the pathophysiology of disease.

Nathanael Gray

Professor of Biological Chemistry and Molecular Pharmacology

Our group seeks to define and understand the mechanisms leading to tumorigenesis. We focus on elucidating the protein kinases responsible for specific cancers and developing small molecule inhibitors of these kinases as tools for discovery and as potential therapeutics.

Stephen Haggarty

Associate Professor of Neurology

ChemicaChemical neurobiology of neuropsychiatric disorders:  We use chemical biology along with molecular and cell biology approaches to understand how the nervous system functions in health and disease. We are particularly interesteinterested in the molecular mechanisms of neuroplasticity and how these are affected in psychiatric and neurodegenerative disorders and may be targeted therapeutically.

Marcia Haigis

Associate Professor of Pathology

Our laboratory focuses on understanding the role that mitochondria play in mammalian aging and disease.

Wade Harper

Bert and Natalie Vallee Professor of Molecular Pathology; Head of the Department of Cell Biology

The Harper laboratory uses quantitative methods to elucidate the network architecture and molecular mechanisms underlying the ubiquitin and autophagy protein homeostasis systems.

Jacob Hooker

Associate Professor of Radiology

Basic reaction methodology development for short-lived isotopes and the application of these new methods to the construction of novel PET imaging agents to probe humann brain function.

Deborah Hung

Associate Professor of Microbiology and Immunobiology

Dr. Hung is working at the interface of chemical biology, infectious disease, and genetic/genomics to better understand the host-bacterial pathogen interaction and explore new paradigms for how to intervene on infection therapeutically.  She has been developing and exploring models to identify molecules that disrupt the pathogen-host interaction or alter bacterial behavior under conditions used to model in vivo infection. 

Eric Jacobsen

Sheldon Emery Professor of Chemistry Chair, Department of Chemistry and Chemical Biology

Mechanistic and synthetic chemistry.

Cigall Kadoch

Assistant Professor of Pediatrics

The central focus of our laboratory is to understand BAF complex pathway-of-assembly, to determine the complex subunit and associated protein factor composition of oncogenic BAF complexes, and to define the mechanistic basis of locus-specific and genome-wide retargeting.

Daniel Kahne

Professor of Chemistry and Chemical Biology and of Biological Chemistry and Molecular Pharmacology Co-Director, Chemical Biology PhD Program

Mechanisms of various antibiotics that kill Gram-negative bacteria and the fundamental cellular processes they inhibit.

Rakesh Karmacharya

Associate Professor of Psychiatry

Chemical biology approaches in the study of neuropsychiatric disorders.

Justin Kim

Assistant Professor of BCMP

Development of chemical tools for the study and manipulation of biological systems.

Randy King

Professor of Cell Biology

Chemical biology of mitosis and the ubiquitin-proteasome system.

Andrew Kruse

Assistant Professor of BCMP

Our research aims to elucidate the molecular basis of signaling using protein engineering and biophysical methods including X-ray crystallography.

Brian Liau

Assistant Professor of Chemistry and Chemical Biology

Our central goal is to develop novel chemical biology and functional genomic approaches to illuminate molecular mechanisms in epigenetics and gene regulation, while exploring the promise of chromatin regulators as therapeutic targets for cancer.

Stephen Liberles

Assistant Professor of Cell Biology

Molecules, receptors, and neural circuits involved in olfaction and instinctive behavior.

David Liu

Professor of Chemistry and Chemical Biology

David R. Liu is Professor of Chemistry and Chemical Biology at Harvard University, Howard Hughes Medical Institute Investigator, and Vice-Chair of the Faculty of the Broad Institute.  His research integrates chemistry and evolution to illuminate biology and enable novel therapeutics through the development and application of powerful technologies, including DNA-templated synthesis (DTS), phage-assisted continuous evolution (PACE), and base editing, a genome editing method that converts a specified base pair to a different base pair in living cells without cutting DNA.  He has also founded several therapeutics companies.

Joseph Loparo

Associate Professor of BCMP

The Loparo lab develops and applies single-molecule approaches to study the mechanisms of genomic maintenance

Ralph Mazitschek

Assistant Professor in Radiology

Development of modulators of chromatin modifying enzymes in particular classII HDACs.

Timothy Mitchison

Hasib Sabbagh Professor of Systems Biology, Deputy Chair, Systems Biology PhD Program co-Director

Cytoskeleton dynamics; mechanism of mitosis and cell locomotion; small molecule inhibitors.

Vamsi Mootha

Professor of Medicine and of Systems Biology

The Mootha lab aims to characterize the structure and dynamic properties of the biological networks underlying mitochondrial function, link variation in these parameters to genetic variation, and exploit the network properties of the organelle to design therapies for human disease.

Jun Qi

Assistant Profess of Medicine

Our research focuses on exploring novel therapeutic strategies for cancer through a multi-disciplinary approach, including synthetic chemistry, medicinal chemistry, chemical biology, computational biology, and biology.  We study gene regulatory pathways including epigenetic proteins, chromatin modification enzymes, and transcription factors. We seek understanding of the biological relevance of these targets in cancer, as well as develop novel therapeutic strategy.

Tom Roberts

Professor of Biological Chemistry and Molecular Pharmacology

Kinases, kinase inhibitors, cancer and aging. We work in wide variety of model systems and utilize approaches varying from systems biology to zebrafish genetics.

Adrian Salic

Associate Professor of Cell Biology

The Hedgehog signaling pathway has critical roles in the embryonic development, in maintaining stem cells and in human cancer. We use biochemistry, cell and chemical biology to understand how vertebrate cells send and interpret Hedgehog signals. We also develop new chemical tools within the area of cell-cell signaling and cell cycle.

Stuart Schreiber

Morris Loeb Professor of Chemistry and Chemical Biology

By examining a series of alleles linked to a disease, we can learn the effect of modulating candidate therapeutic targets in terms of both efficacy and safety. This approach to therapeutic discovery requires that we innovate chemical biology; for example, by discovering small molecules that impart on a therapeutic target the biochemical mechanism of disease protection seen with protective alleles.

Matthew Shair

Professor of Chemistry and Chemical Biology

Organic synthesis and chemical biology.

Susan Shao

Assistant Professor of Cell Biology

We aim to understand the molecular mechanisms that determine the fate of new proteins using in vitro reconstitution, cell biology, and structural biology approaches.

Pamela Silver

Professor of Systems Biology

The Silver Lab works at the interface between systems and synthetic biology to design and build biological systems in both mammalian and prokaryotic cells. Some current projects include analysis of cells that remember past events, cell-based computation and therapeutics, and metabolic engineering for bio-energy and sustainability.

Piotr Sliz

Associate Professor of Pediatrics and of Biological Chemistry and Molecular Pharmacology

microRNA biogenesis and structural biology computing

Peter Sorger

Professor of Systems Biology

The Sorger lab applies experimental and computational methods to the analysis of mechanical and regulatory processes controlling eukaryotic cell division. They seek to construct data-driven, systems-wide models of cellular function that contain detailed mechanistic information on the activities of individual proteins.

Radhika Subramanian

Assistant Professor or Genetics

Reconstituting micron-scale cellular structures from nanometer-sized proteins.

Loren Walensky

Associate Professor of Pediatrics

Chemical biology of deregulated apoptotic and transcriptional pathways in cancer.

Suzanne Walker

Professor of Microbiology and Molecular Genetics Co-Director, Chemical Biology PhD Program

Mechanisms of various antibiotics that kill Gram-negative bacteria and the fundamental cellular processes they inhibit.

Christina Woo

Assistant Professor of Chemistry and Chemical Biology

The Woo lab studies small molecules in the proteome using chemical biology, organic chemistry, and mass spectrometry.

Hao Wu

Professor of Biological Chemistry and Molecular Pharmacology; Professor of Pediatrics

The Wu laboratory of structural immunology focuses on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors.  We are especially interested in the formation of supramolecular signaling complexes (“signalosomes”) upon receptor activation and their implications in cell signaling properties.

Xu Wu

Associate Professor of Dermatology

The Wu laboratory is interested in using chemical biology and functional genomics approaches to study lipid biology, developmental signaling networks and cellular processes in normal physiology and diseases.

Priscilla Yang

Associate Professor of Microbiology and Molecular Genetics

My group utilizes chemical tools to study the interaction of viral pathogens with the host cell. We are especially interested in using chemical tools to elucidate molecular mechanisms underlying the replication of viral pathogens to pioneer and validate new antiviral targets and strategies.

Yi Zhang

Assistant Professor of Genetics

The Zhang lab is interested in how chemical modifications in chromatin affect gene expression and various biological processes, including preimplantation development, stem cell reprogramming, reward-related learning and memory, etc.

Xiaowei Zhuang

Professor of Chemistry and Chemical Biology and of Physics

The Zhaung Lab's research is focused on three major directions: (1) Developing super-resolution optical microscopy that allows cell and tissue imaging with molecular-scale resolution and applying this technology to cell biology and neurobiology, (2) Studying how biomolecules function, especially how proteins and nucleic acids interact, using single-molecule imaging; (3) Developing live-cell imaging techniques and investigating virus-cell interactions using live-cell imaging.

Len Zon

Professor of Stem Cell and Regenerative Biology Grousbeck Professor of Pediatrics

Utilizing the zebrafish as a model system, the Zon Laboratory focuses on the developmental biology of hematopoiesis and cancer.