Professor of Chemistry and Chemical Biology and of Physics
12 Oxford Street
Cambridge, MA, 02138
Lab Size: Between 15 and 20
The Zhuang research lab develops and applies advanced optical imaging techniques to study the behavior of individual biological molecules and complexes in vitro and in live cells.
Our current research is focused on three major directions: (1) Developing super-resolution optical microscopy that allows cell and tissue imaging with molecular-scale resolution and applying this technology to cell biology and neurobiology, (2) Studying how biomolecules function, especially how proteins and nucleic acids interact, using single-molecule imaging; (3) Developing live-cell imaging techniques and investigating virus-cell interactions using live-cell imaging.
T. Blosser, J. Yang, M. Stone, G. Narlikar, X. Zhuang, Dynamics of nucleosome remodeling by individual ACF complexes. Nature 462, 1022-1027 (2009)
E. Abbondanzieri, G. Bokinsky, J. W. Rausch, J. X. Zhang, S. F. J. Le Grice, X. Zhuang. Dynamic binding orientations direct activity of HIV reverse transcriptase. Nature 453, 184-189 (2008).
B. Huang, W. Wang, M. Bates, X. Zhuang. Three-dimensional super-resolution imaging by stochastic optical reconstruction microscopy. Science 319, 810-813 (2008).
M. Bates, B. Huang, G. Dempsey, X. Zhuang. Multicolor super-resolution imaging with photo-switchable fluorescent probes. Science 317, 1749-1753 (2007).
M. Lakadamyali, M. J. Rust, X. Zhuang. Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes. Cell 124, 997-1009 (2006).