Professor of Chemistry and Chemical Biology and of Physics
Mallikcrodt Building, Room 115
12 Oxford St.
Cambridge, MA 02138
Lab Size: Between 5 and 10
My lab develops new physical tools to study molecules and cells, and we apply these tools to make new measurements. We combine nanofabrication, optics, microfluidics, electronics, and biochemistry to generate data; and we apply statistics and physical modeling to understand the data. Current projects include: development of nanofabricated devices for trapping and studying single biomolecules in free solution; development of fluorescent voltage-indicating proteins; studies on optical spectroscopy in highly contorted electromagnetic fields; experiments on magnetically sensitive photochemical reactions; and studies of the mechanochemistry of biological hydrogels.
J. Kralj*, A. D. Douglass*, D. R. Hochbaum*, D. Maclaurin, A. E. Cohen, “Optical recording of action potentials in mammalian neurons using a microbial rhodopsin,” Nature Methods, 9, 90-95 (2012)
J. Kralj, D. R. Hochbaum, A. D. Douglass, A. E. Cohen, “Electrical spiking in Escherichia coli probed with a fluorescent voltage-indicating protein,” Science, 333, 345-348 (2011)
A. P. Fields, A. E. Cohen, “Electrokinetic trapping at the one nanometer limit,” Proc. Natl. Acad. Sci. USA, 108, 8937-8942 (2011)
Y. Tang and A. E. Cohen, “Enhanced enantioselectivity in excitation of chiral molecules by superchiral light,” Science, 332, 333-336 (2011)
H. Lee, N. Yang, A. E. Cohen, “Mapping nanomagnetic fields using a radical pair reaction,” Nano Letters, 11, 5367-5372 (2011)