Viewing how neurons work (Cohen)

In oncology, the notion of personalized medicine — in which genetic tools can be used precisely to characterize a patient’s cancer and tailor treatment to a genetic profile — is now all but standard practice.

Though personalized treatments for diseases like amyotrophic lateral sclerosis (ALS), epilepsy, and bipolar disorders have remained frustratingly out of reach for neurologists, Harvard scientists say that could soon change.

A new technique for observing neural activity, developed by Adam Cohen, professor of chemistry and chemical biology and of physics, and colleagues including Venkatesh Murthy, professor of molecular and cellular biology, and Bernardo Sabatini, the Takeda Professor of Neurobiology at Harvard Medical School, will allow scientists to stimulate neurons and observe their firing pattern in real time. Tracing those neural pathways can help researchers answer questions about how neural signals propagate, and could one day allow doctors to design individualized treatments for a host of disorders. The study is described in a paper in Nature Methods.

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